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Gut Microbes. 2016 Jul 3;7(4):323-328. Epub 2016 Mar 3.

Step-up fecal microbiota transplantation (FMT) strategy.

Cui B1,2, Li P1,2, Xu L1,2, Peng Z1,2, Xiang J1,2, He Z1,2, Zhang T1,2, Ji G1,2, Nie Y3, Wu K3, Fan D3, Zhang F1,2.

Author information

1
a Medical Center for Digestive Diseases , the Second Affiliated Hospital of Nanjing Medical University , Nanjing , China.
2
b Key Lab of Holistic Integrative Enterology , Nanjing Medical University , Nanjing , China.
3
c State Key Laboratory of Cancer Biology & Xijing Hospital of Digestive Diseases , the Fourth Military Medical University , Xi'an , China.

Abstract

Gut dysbiosis is a characteristic of inflammatory bowel disease (IBD) and is believed to play a role in the pathogenesis of IBD. Fecal microbiota transplantation (FMT) is an effective strategy to restore intestinal microbial diversity and has been reported to have a potential therapeutic value in IBD. Our recent study reported a holistic integrative therapy called "step-up FMT strategy," which was beneficial in treating steroid-dependent IBD patients. This strategy consists of scheduled FMTs combined with steroids, anti-TNF-α antibody treatment or enteral nutrition. Herein, we will elaborate the strategy thoroughly, introducing the concept, potential indication, methodology, and safety of "step-up FMT strategy" in detail.

KEYWORDS:

Inflammatory bowel disease; Step-up fecal microbiota transplantation; Steroids; Ulcerative colitis; dysbiosis

PMID:
26939622
PMCID:
PMC4988439
DOI:
10.1080/19490976.2016.1151608
[Indexed for MEDLINE]
Free PMC Article

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