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Mol Microbiol. 1989 Oct;3(10):1455-9.

The Yersinia yop regulon.

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Unité de Microbiologie, Université Catholique de Louvain, Brussels, Belgium.


Growth of yersiniae is restricted at 37 degrees C in the absence of calcium ions. This phenomenon correlates with the massive release of a set of proteins called Yops. Growth restriction and Yops production are governed by a 70 kb plasmid called pYV. yop genes are distributed throughout pYV and constitute a thermoactivated regulon controlled by the gene virF. The transcription activator VirF is a member of a new family of regulators including those of the arabinose and rhamnose operons as well as a regulator of enteric colonization pili. The role of calcium ions on the release of Yops remains largely unknown.

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