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Genet Med. 2016 Oct;18(10):1020-8. doi: 10.1038/gim.2015.210. Epub 2016 Mar 3.

Clinical utility of a Web-enabled risk-assessment and clinical decision support program.

Author information

1
Duke Center for Applied Genomics & Precision Medicine, Duke University, Durham, North Carolina, USA.
2
Duke Department of Medicine, Duke University, Durham, North Carolina, USA.
3
Genomic Medicine Institute, Geisinger Health System, Danville, Pennsylvania, USA.
4
Center for Biotechnology, Genomics, and Health Research, University of North Carolina-Greensboro, Greensboro, North Carolina, USA.
5
Center for Human Genomics, Department of Medicine, Duke University and Epidemiological Research and Information Center, Durham VA Medical Center, Durham, North Carolina, USA.

Abstract

PURPOSE:

Risk-stratified guidelines can improve quality of care and cost-effectiveness, but their uptake in primary care has been limited. MeTree, a Web-based, patient-facing risk-assessment and clinical decision support tool, is designed to facilitate uptake of risk-stratified guidelines.

METHODS:

A hybrid implementation-effectiveness trial of three clinics (two intervention, one control).

PARTICIPANTS:

consentable nonadopted adults with upcoming appointments.

PRIMARY OUTCOME:

agreement between patient risk level and risk management for those meeting evidence-based criteria for increased-risk risk-management strategies (increased risk) and those who do not (average risk) before MeTree and after.

MEASURES:

chart abstraction was used to identify risk management related to colon, breast, and ovarian cancer, hereditary cancer, and thrombosis.

RESULTS:

Participants = 488, female = 284 (58.2%), white = 411 (85.7%), mean age = 58.7 (SD = 12.3). Agreement between risk management and risk level for all conditions for each participant, except for colon cancer, which was limited to those <50 years of age, was (i) 1.1% (N = 2/174) for the increased-risk group before MeTree and 16.1% (N = 28/174) after and (ii) 99.2% (N = 2,125/2,142) for the average-risk group before MeTree and 99.5% (N = 2,131/2,142) after. Of those receiving increased-risk risk-management strategies at baseline, 10.5% (N = 2/19) met criteria for increased risk. After MeTree, 80.7% (N = 46/57) met criteria.

CONCLUSION:

MeTree integration into primary care can improve uptake of risk-stratified guidelines and potentially reduce "overuse" and "underuse" of increased-risk services.Genet Med 18 10, 1020-1028.

PMID:
26938783
DOI:
10.1038/gim.2015.210
[Indexed for MEDLINE]

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