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Neuron. 2016 Mar 2;89(5):881-4. doi: 10.1016/j.neuron.2016.02.022.

Inside Out: Core Network of Transcription Factors Drives Axon Regeneration.

Author information

1
Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
2
Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. Electronic address: rgiger@med.umich.edu.

Abstract

In this issue, Chandran et al. (2016) pursue a multi-level bioinformatics approach combined with wet bench validation to identify gene networks associated with the regenerative state of injured adult sensory neurons. A small molecular compound, ambroxol, mimics aspects of the identified gene expression patterns and promotes axon regeneration in the injured adult mouse CNS, demonstrating feasibility of in silico-based methods to identify compounds that promote neuronal growth following CNS injury.

PMID:
26938435
DOI:
10.1016/j.neuron.2016.02.022
[Indexed for MEDLINE]
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