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J Neurol Neurobiol. 2015 Jul;1(3). doi: 10.16966/2379-7150.109. Epub 2015 Jul 25.

Previous Injury and Chronic Pain are Associated with Side of Onset in Parkinson's Disease.

Author information

  • 1Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
  • 2Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA.
  • 3Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
  • 4Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
  • 5Department of Public Health Sciences Pennsylvania State University College of Medicine, Hershey, PA, USA.
  • 6Department of Kinesiology, Statistics8 Pennsylvania State University, University Park, PA, USA.
  • 7Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Neurology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Radiology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, USA; Department of Kinesiology, Pennsylvania State University, University Park, PA, USA.

Abstract

BACKGROUND:

Parkinson's disease (PD) motor symptoms are frequently asymmetric and the factors that influence the side of onset are unclear.

OBJECTIVE:

To explore whether peripheral injury and associated chronic limb pain may influence the side of onset.

METHODS:

We administered a questionnaire to 128 PD patients in a tertiary movement disorder clinic. Handedness, date and type of limb injury(s) and duration of associated pain, and date and side of onset were ascertained.

RESULTS:

Sixty-two subjects reported limb injuries prior to the onset of PD symptoms, 30 with and 32 without chronic pain (i.e., ≥ 2 months). There was no association between injury and PD onset side overall (p=0.334). In subjects with chronic pain associated with limb injuries, however, side of injuries was associated with the side of PD symptom onset (p=0.030).

CONCLUSIONS:

Limb injury with chronic pain may be related to the side of PD symptom onset. Future studies may shed light on the nature of this observation.

KEYWORDS:

Handedness; Parkinson's disease; Peripheral limb injury; Side of onset

PMID:
26937489
PMCID:
PMC4771383
DOI:
10.16966/2379-7150.109
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