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J Int Soc Sports Nutr. 2016 Mar 1;13:8. doi: 10.1186/s12970-016-0118-y. eCollection 2016.

Regulation of mTORC1 by growth factors, energy status, amino acids and mechanical stimuli at a glance.

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1, Waterhoenlaan 25, Zeist, Netherlands.


The mechanistic/mammalian target of rapamycin complex 1 (mTORC1) plays a pivotal role in the regulation of skeletal muscle protein synthesis. Activation of the complex leads to phosphorylation of two important sets of substrates, namely eIF4E binding proteins and ribosomal S6 kinases. Phosphorylation of these substrates then leads to an increase in protein synthesis, mainly by enhancing translation initiation. mTORC1 activity is regulated by several inputs, such as growth factors, energy status, amino acids and mechanical stimuli. Research in this field is rapidly evolving and unraveling how these inputs regulate the complex. Therefore this review attempts to provide a brief and up-to-date narrative on the regulation of this marvelous protein complex. Additionally, some sports supplements which have been shown to regulate mTORC1 activity are discussed.


Akt; Muscle protein synthesis; Myostatin; mTORC1

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