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J Virol. 2016 Apr 29;90(10):4860-4863. doi: 10.1128/JVI.03056-15. Print 2016 May 15.

Hepatitis C Virus Exploitation of Processing Bodies.

Author information

1
Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York, USA.
2
Department of Biological Sciences, The RNA Institute, University at Albany, State University of New York, Albany, New York, USA ctpager@albany.edu.

Abstract

During infection, positive-strand RNA viruses subvert cellular machinery involved in RNA metabolism to translate viral proteins and replicate viral genomes to avoid or disable the host defense mechanisms. Cytoplasmic RNA granules modulate the stabilities of cellular and viral RNAs. Understanding how hepatitis C virus and other flaviviruses interact with the host machinery required for protein synthesis, localization, and degradation of mRNAs is important for elucidating how these processes occur in both virus-infected and uninfected cells.

PMID:
26937026
PMCID:
PMC4859705
DOI:
10.1128/JVI.03056-15
[Indexed for MEDLINE]
Free PMC Article

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