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Protein Cell. 2016 Mar;7(3):159-74. doi: 10.1007/s13238-016-0250-0. Epub 2016 Mar 2.

Role of Notch signaling in regulating innate immunity and inflammation in health and disease.

Author information

1
School of Medicine and Institute for Immunology, Tsinghua University, Beijing, 100084, China.
2
Department of Clinical Medicine, Trinity College Dublin, Dublin, 2, Ireland.
3
School of Medicine and Institute for Immunology, Tsinghua University, Beijing, 100084, China. xiaoyuhu@tsinghua.edu.cn.

Abstract

The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of acute and chronic inflammation. In this review article, we will describe the evidence accumulated during the recent years to support a key regulatory role of the Notch pathway in innate immune and inflammatory responses and discuss the potential implications of such regulation for pathogenesis and therapy of inflammatory disorders.

KEYWORDS:

Notch signaling; RBP-J; inflammation; innate immunity; macrophages

PMID:
26936847
PMCID:
PMC4791423
DOI:
10.1007/s13238-016-0250-0
[Indexed for MEDLINE]
Free PMC Article

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