Format

Send to

Choose Destination
Hum Genomics. 2016 Mar 2;10:8. doi: 10.1186/s40246-016-0065-3.

The impact of common polymorphisms in CETP and ABCA1 genes with the risk of coronary artery disease in Saudi Arabians.

Author information

1
Institute for Research and Medical Consultation, University of Dammam, P.O.Box 1982, Dammam, 31441, Kingdom of Saudi Arabia. ccyrus@uod.edu.sa.
2
Institute for Research and Medical Consultation, University of Dammam, P.O.Box 1982, Dammam, 31441, Kingdom of Saudi Arabia.
3
King Fahd Hospital of the University, University of Dammam, P.O.Box 4001, Al-Khobar, 31952, Kingdom of Saudi Arabia.
4
Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Abstract

BACKGROUND:

Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Many genetic and environmental risk factors including atherogenic dyslipidemia contribute towards the development of CAD. Functionally relevant mutations in the dyslipidemia-related genes and enzymes involved in the reverse cholesterol transport system are associated with CAD and contribute to increased susceptibility of myocardial infarction (MI).

METHOD:

Blood samples from 990 angiographically confirmed Saudi CAD patients with at least one event of myocardial infarction were collected between 2012 and 2014. A total of 618 Saudi controls with no history or family history of CAD participated in the study. Four polymorphisms, rs2230806, rs2066715 (ABCA1), rs5882, and rs708272 (CETP), were genotyped using TaqMan Assay.

RESULTS:

CETP rs5882 (OR = 1.45, P < 0.005) and ABCA1 rs2230806 (OR = 1.42, P = 0.017) polymorphisms were associated with increased risk of CAD. However, rs708272 polymorphism showed protective effect (B1 vs. B2: OR = 0.80, P = 0.003 and B2B2 vs. B1B1: OR = 0.68, P = 0.012) while the ABCA1 variant rs2066715 was not associated.

CONCLUSION:

This study is the first to report the association of these polymorphisms with CAD in the population of the Eastern Province of Saudi Arabia. The rs5882 polymorphism (CETP) showed a significant association and therefore could be a promising marker for CAD risk estimation while the rs708272 polymorphism had a protective effect from CAD.

PMID:
26936456
PMCID:
PMC4776394
DOI:
10.1186/s40246-016-0065-3
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center