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Sci Rep. 2016 Mar 3;6:22631. doi: 10.1038/srep22631.

Maternal serum cadmium level during pregnancy and its association with small for gestational age infants: a population-based birth cohort study.

Wang H1,2, Liu L1, Hu YF1, Hao JH1,2, Chen YH1,2, Su PY1,2, Fu L1, Yu Z1, Zhang GB1, Wang L1, Tao FB1,2, Xu DX1,2.

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School of Public Health, Anhui Medical University; Hefei, China.
Anhui Provincial Key Laboratory of Population Health &Aristogenics, Hefei, China.


The association between maternal cadmium (Cd) exposure during pregnancy and the increased risk of fetal growth restriction (FGR) remains controversial. The present study evaluated the association between maternal serum Cd level and risk of small for gestational age (SGA) infants in a Chinese population. The present study analyzed a subsample of the C-ABCS cohort that recruited 3254 eligible mother-and-singleton-offspring pairs. Maternal serum Cd level during pregnancy was measured by graphite furnace atomic absorption spectrometry. The rate and odds ratio (OR) for SGA infant were calculated. The rate for SGA infant was 10.6% among subjects with H-Cd (≥1.06 μg/L), significantly higher than 7.5% among subjects with L-Cd (<1.06 μg/L). OR was 1.45 (95% CI: 1.11, 1.90; P = 0.007) among subjects with H-Cd. Adjusted OR for SGA infants was 1.43 (95% CI: 1.09, 1.88; P = 0.007) among subjects with H-Cd. Taken together, we observe the fact that maternal Cd exposure at middle gestational stage, elevates the risk of SGA in contrast to early gestational stage. The present results might be interesting and worth more discussing, and guarantee to further studies.

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