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Oncotarget. 2016 Mar 15;7(11):11881-8. doi: 10.18632/oncotarget.7691.

The effect of D-serine administration on cognition and mood in older adults.

Author information

1
Biomedical Sciences Institute, Federal University of Rio de Janeiro, RJ, Brazil.
2
Institute of Psychiatry, Federal University of Rio de Janeiro, RJ, Brazil.
3
Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom.
4
Institute of Biology Roberto Alcantara Gomes, Biomedical Center, State University of Rio de Janeiro, RJ, Brazil.
5
Integrated Unit for Prevention, Adventist Silvestre Hospital, Rio de Janeiro, RJ, Brazil.

Abstract

BACKGROUND:

D-serine is an endogenous co-agonist of the N-Methyl D-Aspartate Receptor (NMDAR) that plays a crucial role in cognition including learning processes and memory. Decreased D-serine levels have been associated with age-related decline in mechanisms of learning and memory in animal studies. Here, we asked whether D-serine administration in older adults improves cognition.

RESULTS:

D-serine administration improved performance in the Groton Maze learning test of spatial memory and learning and problem solving (F(3, 38)= 4.74, p = 0.03). Subjects that achieved higher increases in plasma D-serine levels after administration improved more in test performance (r2=-0.19 p = 0.009). D-serine administration was not associated with any significant changes in the other cognitive tests or in the mood of older adults (p > 0.05).

METHODS:

Fifty healthy older adults received D-serine and placebo in a randomized, double blind, placebo-controlled, crossover design study. We studied the effect of D-serine administration on the performance of cognitive tests and an analogue mood scale. We also collected blood samples to measure D-serine, L-serine, glutamate and glutamine levels.

CONCLUSIONS:

D-serine administration may be a strategy to improve spatial memory, learning and problem solving in healthy older adults. Future studies should evaluate the impact of long-term D-serine administration on cognition in older adults.

KEYWORDS:

D-serine; Gerotarget; aging; cognition; glutamate metabolism; mood

PMID:
26933803
PMCID:
PMC4914255
DOI:
10.18632/oncotarget.7691
[Indexed for MEDLINE]
Free PMC Article

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