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Cell Chem Biol. 2016 Jan 21;23(1):31-44. doi: 10.1016/j.chembiol.2015.11.012.

New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products.

Author information

1
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
2
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Department of Chemistry, Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address: vddonk@illinois.edu.

Abstract

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a large group of structurally diverse natural products. Their biological activities and unique biosynthetic pathways have sparked a growing interest in RiPPs. Furthermore, the relatively low genetic complexity associated with RiPP biosynthesis makes them excellent candidates for synthetic biology applications. This Review highlights recent developments in the understanding of the biosynthesis of several bacterial RiPP family members, the use of the RiPP biosynthetic machinery for generating novel macrocyclic peptides, and the implementation of tools designed to guide the discovery and characterization of novel RiPPs.

PMID:
26933734
PMCID:
PMC4779184
DOI:
10.1016/j.chembiol.2015.11.012
[Indexed for MEDLINE]
Free PMC Article

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