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Rep Pract Oncol Radiother. 2016 Mar-Apr;21(2):95-101. doi: 10.1016/j.rpor.2014.11.004. Epub 2014 Dec 12.

Present status of Accelerator-Based BNCT.

Author information

1
Gerencia de Investigación y Aplicaciones, CNEA, Av Gral Paz 1499, 1650 San Martin, Argentina; Escuela de Ciencia y Tecnología, Universidad de San Martín, Argentina; CONICET, Argentina.
2
Gerencia de Investigación y Aplicaciones, CNEA, Av Gral Paz 1499, 1650 San Martin, Argentina.
3
Gerencia de Investigación y Aplicaciones, CNEA, Av Gral Paz 1499, 1650 San Martin, Argentina; Escuela de Ciencia y Tecnología, Universidad de San Martín, Argentina.
4
Gerencia de Investigación y Aplicaciones, CNEA, Av Gral Paz 1499, 1650 San Martin, Argentina; CONICET, Argentina.
5
Faculty of Engineering, UBA, Argentina.

Abstract

AIM:

This work aims at giving an updated report of the worldwide status of Accelerator-Based BNCT (AB-BNCT).

BACKGROUND:

There is a generalized perception that the availability of accelerators installed in hospitals, as neutron sources, may be crucial for the advancement of BNCT. Accordingly, in recent years a significant effort has started to develop such machines.

MATERIALS AND METHODS:

A variety of possible charged-particle induced nuclear reactions and the characteristics of the resulting neutron spectra are discussed along with the worldwide activity in suitable accelerator development.

RESULTS:

Endothermic (7)Li(p,n)(7)Be and (9)Be(p,n)(9)B and exothermic (9)Be(d,n)(10)B are compared. In addition to having much better thermo-mechanical properties than Li, Be as a target leads to stable products. This is a significant advantage for a hospital-based facility. (9)Be(p,n)(9)B needs at least 4-5 MeV bombarding energy to have a sufficient yield, while (9)Be(d,n)(10)B can be utilized at about 1.4 MeV, implying the smallest possible accelerator. This reaction operating with a thin target can produce a sufficiently soft spectrum to be viable for AB-BNCT. The machines considered are electrostatic single ended or tandem accelerators or radiofrequency quadrupoles plus drift tube Linacs.

CONCLUSIONS:

(7)Li(p,n)(7)Be provides one of the best solutions for the production of epithermal neutron beams for deep-seated tumors. However, a Li-based target poses significant technological challenges. Hence, Be has been considered as an alternative target, both in combination with (p,n) and (d,n) reactions. (9)Be(d,n)(10)B at 1.4 MeV, with a thin target has been shown to be a realistic option for the treatment of deep-seated lesions.

KEYWORDS:

Accelerator-Based BNCT; Different nuclear reactions and accelerator types; Worldwide activity

PMID:
26933390
PMCID:
PMC4747659
[Available on 2017-03-01]
DOI:
10.1016/j.rpor.2014.11.004

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