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J Gen Virol. 2016 May;97(5):1060-1065. doi: 10.1099/jgv.0.000440. Epub 2016 Mar 1.

Discovery of hantavirus circulating among Rattus rattus in French Mayotte island, Indian Ocean.

Author information

1
Institut Pasteur, Unité des Stratégies Antivirales, F-75015, Paris, France.
2
INRA, UMR 1062 CBGP, F-34988 Montferrier-sur-Lez, France and Institut de Biologie Computationnelle, 34095 Montpellier, France.
3
Anses-Laboratoire de Lyon, Unité de Virologie, Lyon, France.
4
Centre de Recherche Clinique, Hôpital Croix Rousse, Lyon, France.
5
Wildlife Zoonoses and Vector-borne Diseases Research Group, Animal and Plant Health Agency, Woodham Lane, New Haw, Surrey, KT15 3NB, UK.
6
Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, UK.
7
UR346 Animal Epidemiology, INRA, Saint Genès Champanelle, France.
8
Mérial, Lyon, France.

Abstract

Hantaviruses are emerging zoonotic viruses that cause human diseases. In this study, sera from 642 mammals from La Réunion and Mayotte islands (Indian Ocean) were screened for the presence of hantaviruses by molecular analysis. None of the mammals from La Réunion island was positive, but hantavirus genomic RNA was discovered in 29/160 (18 %) Rattus rattus from Mayotte island. The nucleoprotein coding region was sequenced from the liver and spleen of all positive individuals allowing epidemiological and intra-strain variability analyses. Phylogenetic analysis based on complete coding genomic sequences showed that this Murinae-associated hantavirus is a new variant of Thailand virus. Further studies are needed to investigate hantaviruses in rodent hosts and in Haemorrhagic Fever with Renal Syndrome (HFRS) human cases.

PMID:
26932442
PMCID:
PMC4851257
DOI:
10.1099/jgv.0.000440
[Indexed for MEDLINE]
Free PMC Article

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