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Mult Scler. 2016 Dec;22(14):1883-1887. Epub 2016 Mar 1.

Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients.

Author information

1
Vascular Immunology Unit, Discipline of Pathology, Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia anna.zinger@sydney.edu.au.
2
Vascular Immunology Unit, Discipline of Pathology, Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia.
3
Cellular Photoimmunology Group, Discipline of Infectious Diseases and Immunology, Sydney Medical School, The Charles Perkins Centre Hub at The University of Sydney, Camperdown, NSW, Australia.
4
Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia.
5
Vascular Immunology Unit, Discipline of Pathology, Sydney Medical School, The University of Sydney, Camperdown, NSW, Australia/Brain and Mind Centre, The University of Sydney, Camperdown, NSW, Australia/Central West Neurology & Neurosurgery, Orange, NSW, Australia.

Abstract

BACKGROUND:

No molecular marker can monitor disease progression and treatment efficacy in multiple sclerosis (MS). Circulating microparticles represent a potential snapshot of disease activity at the blood brain barrier.

OBJECTIVES AND METHODS:

To profile plasma microparticles by flow cytometry in MS and determine how fingolimod could impact endothelial microparticles production.

RESULTS:

In non-treated MS patients compared to healthy and fingolimod-treated patients, endothelial microparticles were higher, while B-cell-microparticle numbers were lower. Fingolimod dramatically reduced tumour necrosis factor (TNF)-induced endothelial microparticle release in vitro.

CONCLUSION:

Fingolimod restored dysregulated endothelial and B-cell-microparticle numbers, which could serve as a biomarker in MS.

KEYWORDS:

B cells; Multiple sclerosis; biological marker; fingolimod; immunology; plasma microparticles; vascular endothelium

PMID:
26931477
DOI:
10.1177/1352458516636959
[Indexed for MEDLINE]

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