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Eur J Cell Biol. 1989 Oct;50(1):162-9.

Expression of a muscle-type alpha-actinin cDNA clone in non-muscle cells.

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Department of Biochemistry, University of Leicester, United Kingdom.


We have previously isolated a chick smooth muscle-type alpha-actinin cDNA clone (C17) from a chick embryo fibroblast cDNA library. As part of an investigation into a possible role for a muscle isoform of alpha-actinin in non-muscle cells, we have cloned C17 into a eucaryotic expression vector, pKCR3, and examined the distribution of the expressed protein in non-muscle, monkey COS cells. We report here that the muscle isoform of chick alpha-actinin encoded by C17, was found in focal contacts and periodically distributed along actin filaments.

[Indexed for MEDLINE]

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