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Angew Chem Int Ed Engl. 2016 Mar 24;55(14):4537-41. doi: 10.1002/anie.201601276. Epub 2016 Mar 1.

Stretchable Electrochemical Sensor for Real-Time Monitoring of Cells and Tissues.

Author information

1
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China.
2
Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
3
Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China. whhuang@whu.edu.cn.

Abstract

Stretchable electrochemical sensors are conceivably a powerful technique that provides important chemical information to unravel elastic and curvilinear living body. However, no breakthrough was made in stretchable electrochemical device for biological detection. Herein, we synthesized Au nanotubes (NTs) with large aspect ratio to construct an effective stretchable electrochemical sensor. Interlacing network of Au NTs endows the sensor with desirable stability against mechanical deformation, and Au nanostructure provides excellent electrochemical performance and biocompatibility. This allows for the first time, real-time electrochemical monitoring of mechanically sensitive cells on the sensor both in their stretching-free and stretching states as well as sensing of the inner lining of blood vessels. The results demonstrate the great potential of this sensor in electrochemical detection of living body, opening a new window for stretchable electrochemical sensor in biological exploration.

KEYWORDS:

electrochemical detection; endothelial cells; gold nanotubes; stretchable sensor; vascular tissue

PMID:
26929123
DOI:
10.1002/anie.201601276
[Indexed for MEDLINE]

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