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Phytother Res. 2016 May;30(5):848-54. doi: 10.1002/ptr.5593. Epub 2016 Mar 1.

Polygonum aviculare L. and its active compounds, quercitrin hydrate, caffeic acid, and rutin, activate the Wnt/β-catenin pathway and induce cutaneous wound healing.

Seo SH1,2, Lee SH1,2, Cha PH1,2, Kim MY1,2, Min do S3, Choi KY1,2.

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Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Department of Molecular Biology, College of Natural Science, Pusan National University, Busan, 609-735, Korea.


Polygonum aviculare L. is a member of the Polygonaceae family of plants, which has been known for its antioxidant and anti-obesity effects. However, the wound healing function of P. aviculare extract has not been assessed. In this study, we identified a novel property of P. aviculare extract as a Wnt/β-catenin pathway activator based on a screen of 350 plant extracts using HEK293-TOP cells retaining the Wnt/β-catenin signaling reporter gene. P. aviculare extract accelerated the migration of HaCaT keratinocytes without showing significant cytotoxicity. Moreover, P. aviculare extract efficiently re-epithelized wounds generated on mice. Additionally, ingredients of P. aviculare extract, such as quercitrin hydrate, caffeic acid, and rutin, also accelerated the motility of HaCaT keratinocytes with the activation of Wnt/β-catenin signaling. Therefore, based on our findings, P. aviculare extract and its active ingredients could be potential therapeutic agents for wound healing.


Polygonum aviculare L; Wnt/β-catenin pathway; caffeic acid; cutaneous wound healing; quercitrin hydrate; rutin

[Indexed for MEDLINE]

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