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Biosci Biotechnol Biochem. 2016 Jun;80(6):1172-8. doi: 10.1080/09168451.2016.1148573. Epub 2016 Mar 1.

Inhibitory effects of geranium essential oil and its major component, citronellol, on degranulation and cytokine production by mast cells.

Author information

1
a Faculty of Human Life Sciences, Department of Food and Nutrition , Senri Kinran University , Suita , Japan.
2
b Research and Development Center , Nagaoka Perfumery Co., Ltd. , Ibaraki , Japan.

Abstract

We investigated the effects of geranium essential oil (GEO) on anaphylaxis. GEO can exert antioxidant and anti-inflammatory effects, but its roles in allergic reactions are incompletely understood. Here, we used mouse cells to show that GEO inhibited the degranulation of cultured mast cells (CMCs). Citronellol is the major component of GEO and inhibited CMC degranulation. The l-enantiomer of citronellol more effectively suppressed CMC degranulation than did d-citronellol. We also examined whether citronellol could inhibit the immunoglobulin (Ig) E-induced production of tumor necrosis factor (TNF)-α. Treatment with various concentrations of citronellol before CMC activation with IgE significantly inhibited the induction of TNF-α in a dose-dependent manner. Mechanistically, citronellol suppressed the phosphorylation of mitogen-activated protein kinase (ERK), which is critical for ERK activation and the production of inflammatory cytokines in mast cells. These findings suggest that citronellol may represent a candidate compound for the effective treatment of allergic diseases.

KEYWORDS:

anti-allergic effect; citronellol; cytokine production; degranulation; mast cell

PMID:
26927807
DOI:
10.1080/09168451.2016.1148573
[Indexed for MEDLINE]

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