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Nutrients. 2016 Feb 25;8(3):112. doi: 10.3390/nu8030112.

Diet Quality Scores and Risk of Nasopharyngeal Carcinoma in Chinese Adults: A Case-Control Study.

Author information

1
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. wangch28@mail2.sysu.edu.cn.
2
Department of Gynecologic Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Linxiaol@sysucc.org.cn.
3
Sun Yat-sen University Ophthalmic Center, Guangzhou 510060, China. Fanyy@sysucc.org.cn.
4
Information Section, Central Hospital of Panyu District, Guangzhou 511400, China. tingty@126.com.
5
Department of Radiotherapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China. Zhangxingl@sysucc.org.cn.
6
Sun Yat-sen University Ophthalmic Center, Guangzhou 510060, China. luyunkai@mail.sysu.edu.cn.
7
Clinical laboratory section of the office outpatient Department public security board, Guangdong 510050, China. ladychun@126.com.
8
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China. chenyum@mail.sysu.edu.cn.

Abstract

Many studies show that dietary factors may affect the risk of nasopharyngeal carcinoma (NPC). We examined the association between overall diet quality and NPC risk in a Chinese population. This case-control study included 600 NPC patients and 600 matched controls between 2009 and 2011 in Guangzhou, China. Habitual dietary intake and various covariates were assessed via face-to-face interviews. Diet quality scores were calculated according to the Healthy Eating Index-2005 (HEI-2005), the alternate Healthy Eating Index (aHEI), the Diet Quality Index-International (DQI-I), and the alternate Mediterranean Diet Score (aMed). After adjustment for various lifestyle and dietary factors, greater diet quality scores on the HEI-2005, aHEI, and DQI-I-but not on the aMed-showed a significant association with a lower risk of NPC (p-trends, <0.001-0.001). The odds ratios (95% confidence interval) comparing the extreme quartiles of the three significant scores were 0.47 (0.32-0.68) (HEI-2005), 0.48 (0.33-0.70) (aHEI), and 0.43 (0.30-0.62) (DQI-I). In gender-stratified analyses, the favorable association remained significant in men but not in women. We found that adherence to the predefined dietary patterns represented by the HEI-2005, aHEI, and DQI-I scales predicted a lower risk of NPC in adults from south China, especially in men.

KEYWORDS:

Chinese; adults; case-control study; diet quality; dietary pattern; nasopharyngeal carcinoma

PMID:
26927167
PMCID:
PMC4808842
DOI:
10.3390/nu8030112
[Indexed for MEDLINE]
Free PMC Article

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