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Int J Mol Sci. 2016 Feb 25;17(3):131. doi: 10.3390/ijms17030131.

Mycobacterium tuberculosis: Manipulator of Protective Immunity.

Author information

1
Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa. vanessakorb@gmail.com.
2
Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa. chutur@ukzn.ac.za.
3
Discipline of Medical Biochemistry and Chemical Pathology, University of KwaZulu-Natal, Howard College Campus, King George V Avenue, 4001 Durban, South Africa. Devan_Moodley@hms.harvard.edu.

Abstract

Mycobacterium tuberculosis (MTB) is one of the most successful pathogens in human history and remains a global health challenge. MTB has evolved a plethora of strategies to evade the immune response sufficiently to survive within the macrophage in a bacterial-immunological equilibrium, yet causes sufficient immunopathology to facilitate its transmission. This review highlights MTB as the driver of disease pathogenesis and presents evidence of the mechanisms by which MTB manipulates the protective immune response into a pathological productive infection.

KEYWORDS:

foamy macrophage; granuloma; mycobacterium; tuberculosis

PMID:
26927066
PMCID:
PMC4813124
DOI:
10.3390/ijms17030131
[Indexed for MEDLINE]
Free PMC Article

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