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Ayurvedic. 2015 Nov;2(2):34-38.

Antioxidant Activity of The Ancient Herb, Holy Basil in CCl4-Induced Liver Injury in Rats.

Author information

1
Department of Experimental Pharmacology, Research and Development Unit, Nagarjuna Herbal Concentrates Ltd, Thodupuzha, Kerala, India.
2
CareKeralam Ltd, Koratty, Thrissur Dt, Kerala, India.
3
Sewanthi Ayurvedic Seriers, Vancouver, Canada; World Institute for Scientific Exploration, Baltimore, MD 21210, USA.
4
Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA.
5
World Institute for Scientific Exploration, Baltimore, MD 21210, USA; Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA.

Abstract

An herbal preparation called "holy basil plus herbal powder" (HBPP) containing Ocimum santum, Withania somnifera, Pongamia pinnata, Plumbago indica, Emblica officinalis and Curcuma longa was investigated as an antioxidant and hepatoprotective agent. The antioxidant activity of HBPP was investigated in rats with liver injury induced by oral administration of carbon tetrachloride:olive oil (1:1). HBPP was administered orally at 500 mg/kg daily for 7 days before. HBPP exhibited statistically significant antioxidant activity, as shown by increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD) and catalase (CAT) and decreased level of lipid peroxidation (LPO). HBPP performed equally well as silymarin, a well-established antioxidant preparation used to protect against liver injury.

KEYWORDS:

Holy basil plus herbal powder; antioxidant activity; carbon tetrachloride; hepatoprotection; liver enzymes

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