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Neuron. 2016 Mar 16;89(6):1180-1186. doi: 10.1016/j.neuron.2016.01.045. Epub 2016 Feb 25.

Oscillations Go the Distance: Low-Frequency Human Hippocampal Oscillations Code Spatial Distance in the Absence of Sensory Cues during Teleportation.

Author information

1
Center for Neuroscience, University of California, Davis, 1 Shields Avenue, Davis, CA 95618, USA.
2
Department of Neurology, University of California, Davis Medical Center, 4860 Y Street, Suite 0100, Sacramento, CA 95817, USA.
3
Department of Neurological Surgery, University of California, Davis Medical Center, 4860 Y Street, Suite 0100, Sacramento, CA 95817, USA.
4
Department of Radiology, University of California, Davis Medical Center, 4860 Y Street, Suite 3100, Sacramento, CA 95817, USA.
5
Center for Neuroscience, University of California, Davis, 1 Shields Avenue, Davis, CA 95618, USA; Department of Psychology, University of California, Davis, 1 Shields Avenue, Davis, CA 95618, USA. Electronic address: adekstrom@ucdavis.edu.

Abstract

Low-frequency (delta/theta band) hippocampal neural oscillations play prominent roles in computational models of spatial navigation, but their exact function remains unknown. Some theories propose they are primarily generated in response to sensorimotor processing, while others suggest a role in memory-related processing. We directly recorded hippocampal EEG activity in patients undergoing seizure monitoring while they explored a virtual environment containing teleporters. Critically, this manipulation allowed patients to experience movement through space in the absence of visual and self-motion cues. The prevalence and duration of low-frequency hippocampal oscillations were unchanged by this manipulation, indicating that sensorimotor processing was not required to elicit them during navigation. Furthermore, the frequency-wise pattern of oscillation prevalence during teleportation contained spatial information capable of classifying the distance teleported. These results demonstrate that movement-related sensory information is not required to drive spatially informative low-frequency hippocampal oscillations during navigation and suggest a specific function in memory-related spatial updating.

PMID:
26924436
PMCID:
PMC4795976
DOI:
10.1016/j.neuron.2016.01.045
[Indexed for MEDLINE]
Free PMC Article

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