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Gastroenterology. 2016 Jun;150(8):1786-97. doi: 10.1053/j.gastro.2016.02.043. Epub 2016 Feb 27.

Alcoholic Liver Disease in Asia, Europe, and North America.

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Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana; Roudebush Veterans Administration Medical Center, Indianapolis, Indiana. Electronic address:
Drug Health Services, Royal Prince Alfred Hospital, Sydney Medical School, University of Sydney, Australia.
Centenary Research Institute, AW Morrow GE/Liver Center Australian Liver Transplant Unit Royal Prince Alfred Hospital, University of Sydney, Australia.


Alcoholic liver diseases comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis. Although the relationship between alcohol consumption and liver disease is well established, severe alcohol-related morbidities develop in only a minority of people who consume alcohol in excess. Inter-individual differences in susceptibility to the toxic effects of alcohol have been studied extensively-they include pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. Alcoholic liver disease is becoming more common in many parts of Asia, but is decreasing in Western Europe. Treatment approaches, including availability of medications, models of care, and approach to transplantation, differ among regions.


Alcoholic Liver Disease; Asia; Clinical Profiles; Europe; North America

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