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Allergy Asthma Immunol Res. 2016 May;8(3):198-205. doi: 10.4168/aair.2016.8.3.198.

IgG Sensitization to Extracellular Vesicles in Indoor Dust Is Closely Associated With the Prevalence of Non-Eosinophilic Asthma, COPD, and Lung Cancer.

Author information

1
Asan Institute for Life Science and University of Ulsan College of Medicine, Seoul, Korea.
2
Institute of Convergence Medicine, Ewha Womans University Medical Center and Ewha Womans University School of Medicine, Seoul, Korea.
3
Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
4
Department of Allergy and Clinical Immunology, Asan Medical Center, Seoul, Korea.
5
Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Disease, Asan Medical Center, Seoul, Korea. ymoh55@amc.seoul.kr.
6
Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea. ykjee@dku,edu.
7
Department of Pulmonary and Critical Care Medicine, and Clinical Research Center for Chronic Obstructive Airway Disease, Asan Medical Center, Seoul, Korea.
8
Institute of Convergence Medicine, Ewha Womans University Medical Center and Ewha Womans University School of Medicine, Seoul, Korea. juinea@ewha.ac.kr.

Abstract

PURPOSE:

Recent experimental evidence shows that extracellular vesicles (EVs) in indoor dust induce neurtrophilic pulmonary inflammation, which is a characteristic pathology in patients with severe asthma and chronic obstructive pulmonary disease (COPD). In addition, COPD is known to be an important risk factor for lung cancer, irrespective of cigarette smoking. Here, we evaluated whether sensitization to indoor dust EVs is a risk for the development of asthma, COPD, or lung cancer.

METHODS:

Serum IgG antibodies against dust EVs were measured in 90 healthy control subjects, 294 asthmatics, 242 COPD patients, and 325 lung cancer patients. Serum anti-dust EV IgG titers were considered high if they exceeded a 95 percentile value of the control subjects. Age-, gender-, and cigarette smoke-adjusted multiple logistic regression analyses were performed to determine odds ratios (ORs) for asthma, COPD, and lung cancer patients vs the control subjects.

RESULTS:

In total, 4.4%, 13.6%, 29.3%, and 54.9% of the control, asthma, COPD, and lung cancer groups, respectively, had high serum anti-dust EV IgG titers. Adjusted multiple logistic regression revealed that sensitization to dust EVs (high serum anti-dust EV IgG titer) was an independent risk factor for asthma (adjusted OR, 3.3; 95% confidence interval [CI], 1.1-10.0), COPD (adjusted OR, 8.0; 95% CI, 2.0-32.5) and lung cancer (adjusted OR, 38.7; 95% CI, 10.4-144.3).

CONCLUSIONS:

IgG sensitization to indoor dust EVs appears to be a major risk for the development of asthma, COPD, and lung cancer.

KEYWORDS:

COPD; Extracellular vesicles; IgG sensitization; asthma; indoor dust; lung cancer

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