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Trends Genet. 1989 Oct;5(10):337-42.

Chromosomes of malaria parasites.

Abstract

The advent of pulsed field gradient electrophoresis has proved remarkably useful for studying chromosomes of the genetically intractable malaria parasite Plasmodium falciparum. Advances include determination of the karyotype, a linkage map and restriction maps of individual chromosomes that enable the ordering of genes. The structural basis underlying a frequently occurring form of chromosome size polymorphism is now understood and other polymorphisms are providing tantalizing clues to the mechanisms underlying drug resistance.

PMID:
2692241
DOI:
10.1016/0168-9525(89)90139-x
[Indexed for MEDLINE]

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