Lack of Correlation Between Pulmonary and Systemic Inflammation Markers in Patients with Chronic Obstructive Pulmonary Disease: A Simultaneous, Two-Compartmental Analysis
Arch Bronconeumol. 2016 Jul;52(7):361-7.
doi: 10.1016/j.arbres.2016.01.003.
Epub 2016 Feb 24.
[Article in
English,
Spanish]
Affiliations
- 1 Servei de Pneumologia, Hospital Universitari Son Espases, Palma de Mallorca, España; Instituto de Investigación Sanitaria de Palma (IdisPa), Palma de Mallorca, España; CIBER Enfermedades Respiratorias (CIBERES), España.
- 2 Servei de Pneumologia, Hospital Universitari Son Espases, Palma de Mallorca, España; Instituto de Investigación Sanitaria de Palma (IdisPa), Palma de Mallorca, España; CIBER Enfermedades Respiratorias (CIBERES), España. Electronic address: jaume.sauleda@ssib.es.
- 3 Centre for Research in Environmental Epidemiology (CREAL), Barcelona, España; Departament de Ciències Experimentals i de la Salut (CEXS), Universitat Pompeu Fabra, Barcelona, España; CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, España.
- 4 Servei de Pneumologia, Hospital Universitari Son Espases, Palma de Mallorca, España; Instituto de Investigación Sanitaria de Palma (IdisPa), Palma de Mallorca, España; Servei d'Anàlisis Clíniques, Hospital Universitari Son Espases, Palma de Mallorca, España.
- 5 CIBER Enfermedades Respiratorias (CIBERES), España; Hospital Parc Taulí, Sabadell, Barcelona, España.
- 6 CIBER Enfermedades Respiratorias (CIBERES), España; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, España.
- 7 CIBER Enfermedades Respiratorias (CIBERES), España; Departament de Ciències Experimentals i de la Salut (CEXS), Universitat Pompeu Fabra, Barcelona, España; Grupo de Investigación en Mecanismos de Predisposición al Cáncer de Pulmón, IMIM (Hospital del Mar Medical Research Institute), Barcelona, España; Servei de Pneumologia, Hospital del Mar, Barcelona, España.
- 8 CIBER Enfermedades Respiratorias (CIBERES), España; Institut del Tòrax, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, España.
Abstract
Introduction:
The origin of systemic inflammation in chronic obstructive pulmonary disease (COPD) patients remains to be defined, but one of the most widely accepted hypothesis is the 'spill over' of inflammatory mediators from the lung to the circulation.
Objective:
To evaluate the relationship between pulmonary and systemic inflammation in COPD quantifying several inflammatory markers in sputum and serum determined simultaneously.
Methodology:
Correlations between various inflammatory variables (TNF-α, IL6, IL8) in sputum and serum were evaluated in 133 patients from the PAC-COPD cohort study. A secondary objective was the evaluation of relationships between inflammatory variables and lung function.
Results:
Inflammatory markers were clearly higher in sputum than in serum. No significant correlation was found (absolute value, r=0.03-0.24) between inflammatory markers in blood and in sputum. There were no significant associations identified between those markers and lung function variables, such as FEV1, DLCO and PaO2 neither.
Conclusions:
We found no correlation between pulmonary and systemic inflammation in patients with stable COPD, suggesting different pathogenic mechanisms.
Keywords:
Bronquitis crónica; C-reactive protein; Chronic bronchitis; Citoquinas; Cytokines; Emphysema; Enfisema; Proteína C reactiva.
Copyright © 2016 SEPAR. Published by Elsevier Espana. All rights reserved.
MeSH terms
-
Aged
-
Biomarkers
-
Body Mass Index
-
C-Reactive Protein / analysis
-
Carbon Dioxide / blood
-
Carbon Monoxide / blood
-
Cohort Studies
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Female
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Forced Expiratory Volume
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Humans
-
Inflammation / etiology
-
Inflammation / metabolism*
-
Inflammation Mediators / analysis*
-
Inflammation Mediators / blood
-
Male
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Middle Aged
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Models, Biological
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Oxygen / blood
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Partial Pressure
-
Pulmonary Diffusing Capacity
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Pulmonary Disease, Chronic Obstructive / complications
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Pulmonary Disease, Chronic Obstructive / metabolism*
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Pulmonary Disease, Chronic Obstructive / pathology
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Serum
-
Smoking / metabolism
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Sputum / chemistry*
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Tumor Necrosis Factor-alpha / analysis
Substances
-
Biomarkers
-
Inflammation Mediators
-
Tumor Necrosis Factor-alpha
-
Carbon Dioxide
-
Carbon Monoxide
-
C-Reactive Protein
-
Oxygen