Format

Send to

Choose Destination
Curr Opin Biotechnol. 2016 Aug;40:16-23. doi: 10.1016/j.copbio.2016.02.003. Epub 2016 Feb 25.

Biomaterials approaches to modeling macrophage-extracellular matrix interactions in the tumor microenvironment.

Author information

1
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Graduate Field of Comparative Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.
2
Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA; Graduate Field of Comparative Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA; Kavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, NY 14853, USA. Electronic address: cf99@cornell.edu.

Abstract

Tumors are characterized by aberrant extracellular matrix (ECM) remodeling and chronic inflammation. While advances in biomaterials and tissue engineering strategies have led to important new insights regarding the role of ECM composition, structure, and mechanical properties in cancer in general, the functional link between these parameters and macrophage phenotype is poorly understood. Nevertheless, increasing experimental evidence suggests that macrophage behavior is similarly controlled by physicochemical properties of the ECM and consequential changes in mechanosignaling. Here, we will summarize the current knowledge of macrophage biology and ECM-mediated differences in mechanotransduction and discuss future opportunities of biomaterials and tissue engineering platforms to interrogate the functional relationship between these parameters and their relevance to cancer.

PMID:
26921768
PMCID:
PMC4975673
DOI:
10.1016/j.copbio.2016.02.003
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center