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Eur Child Adolesc Psychiatry. 2016 Oct;25(10):1091-102. doi: 10.1007/s00787-016-0832-7. Epub 2016 Feb 26.

Attenuated psychotic and basic symptom characteristics in adolescents with ultra-high risk criteria for psychosis, other non-psychotic psychiatric disorders and early-onset psychosis.

Author information

1
Department of Neurosciences and Neurorehabilitation, Bambino Gesù Children's Hospital, Rome, Italy.
2
Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy.
3
The Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA.
4
Hofstra North Shore-LIJ School of Medicine, Hofstra University, Hempstead, NY, USA.
5
The Feinstein Institute for Medical Research, Manhasset, NY, USA.
6
Research Unit for Child and Adolescent Psychiatry, Aalborg University Hospital, North Denmark Region, Denmark.
7
School of Medicine, Keio University, Tokyo, Japan.
8
Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome, Rome, Italy.
9
Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA.
10
University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
11
The Zucker Hillside Hospital Department of Psychiatry, North Shore-LIJ Health System, 75-59 263rd Street, Glen Oaks, NY, 11004, USA. ccorrell@lij.edu.
12
Hofstra North Shore-LIJ School of Medicine, Hofstra University, Hempstead, NY, USA. ccorrell@lij.edu.
13
The Feinstein Institute for Medical Research, Manhasset, NY, USA. ccorrell@lij.edu.
14
Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, USA. ccorrell@lij.edu.

Abstract

While attenuated psychotic symptoms (APS) and basic symptoms (BS) are the main current predictors of psychosis in adults, studies in adolescents are scarce. Thus, we (1) described the prevalence and severity of positive, negative, disorganization, general, and basic symptoms in adolescent patients at ultra-high risk for psychosis (UHR), with other non-psychotic psychiatric disorders (PC) and with early-onset psychosis (EOP); and (2) investigated BS criteria in relation to UHR criteria. Sixty-nine 12-18-year-old adolescents (15.3 ± 1.7 years, female = 58.0 %, UHR = 22, PC = 27, EOP = 20) were assessed with the structured interview for prodromal syndromes (SIPS) and the schizophrenia proneness instrument-child and youth version (SPI-CY). Despite similar current and past 12-month global functioning, both UHR and EOP had significantly higher SIPS total and subscale scores compared to PC, with moderate-large effect sizes. Expectedly, UHR had significantly lower SIPS positive symptom scores than EOP, but similar SIPS negative, disorganized, and general symptom scores. Compared to PC, both EOP and UHR had more severe basic thought and perception disturbances, and significantly more often met cognitive disturbances criteria (EOP = 50.0 %, UHR = 40.9 %, PC = 14.8 %). Compared to UHR, both EOP and PC significantly less often met cognitive-perceptive BS criteria (EOP = 35.0 %, UHR = 68.2 %, PC = 25.9 %). BS were significantly more prevalent in both EOP and UHR than PC, and UHR were similar to EOP in symptom domains. Given the uncertain outcome of adolescents at clinical high-risk of psychosis, future research is needed to determine whether the combined assessment of early subjective disturbances with observable APS can improve the accuracy of psychosis prediction.

KEYWORDS:

Adolescents; Basic symptoms; Early detection; Early-onset psychosis; Ultra-high risk

PMID:
26921232
DOI:
10.1007/s00787-016-0832-7
[Indexed for MEDLINE]

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