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Adv Protein Chem Struct Biol. 2016;103:1-23. doi: 10.1016/bs.apcsb.2015.11.002. Epub 2015 Dec 22.

Proteostasis Maintenance of Cys-Loop Receptors.

Author information

1
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
2
Center for Proteomics and Bioinformatics and Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
3
Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. Electronic address: tingwei.mu@case.edu.

Abstract

The Cys-loop receptors play prominent roles in the nervous system. They include γ-aminobutyric acid type A receptors, nicotinic acetylcholine receptors, 5-hydroxytryptamine type-3 receptors, and glycine receptors. Proteostasis represents an optimal state of the cellular proteome in normal physiology. The proteostasis network regulates the folding, assembly, degradation, and trafficking of the Cys-loop receptors, ensuring their efficient functional cell surface expressions. Here, we summarize current advances about the protein biogenesis process of the Cys-loop receptors. Because operating on individual biogenesis steps influences the receptor cell surface level, manipulating the proteostasis network components can regulate the function of the receptors, representing an emerging therapeutic strategy for corresponding channelopathies.

KEYWORDS:

5-HT(3)R; Assembly; Cys-loop receptors; ERAD; Endocytosis; Folding; GABA(A)R; Proteostasis; Trafficking; nAChR

PMID:
26920686
DOI:
10.1016/bs.apcsb.2015.11.002
[Indexed for MEDLINE]

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