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Neurogastroenterol Motil. 2016 Jun;28(6):948-53. doi: 10.1111/nmo.12792. Epub 2016 Feb 27.

Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study.

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University Clinic of Hepato-Gastroenterology, University Hospital, Grenoble, France.
Stress and Neuro-Digestive Interactions, Inserm U1216, Institute of Neurosciences, University Grenoble Alpes, Grenoble, France.
Department of Neurosurgery, University Hospital, Grenoble, France.
Department of Psychology, Savoie University, LIP/PC2S, Chambéry, France.
Department of Neurology, University Hospital, Grenoble, France.
Institute of Biology and Pathology, Laboratory of Protein and Enzyme Biochemistry, University Hospital, Grenoble, France.
Institute of Biology and Pathology, Inserm U1042, HP2, University Hospital, Grenoble, France.
Inserm CIC1406, Clinical Pharmacology Department, University Hospital, Grenoble, France.


The vagus nerve (VN) is a link between the brain and the gut. The VN is a mixed nerve with anti-inflammatory properties through the activation of the hypothalamic-pituitary-adrenal axis by its afferents and by activating the cholinergic anti-inflammatory pathway through its efferents. We have previously shown that VN stimulation (VNS) improves colitis in rats and that the vagal tone is blunted in Crohn's disease (CD) patients. We thus performed a pilot study of chronic VNS in patients with active CD. Seven patients under VNS were followed up for 6 months with a primary endpoint to induce clinical remission and a secondary endpoint to induce biological (CRP and/or fecal calprotectin) and endoscopic remission and to restore vagal tone (heart rate variability). Vagus nerve stimulation was feasible and well-tolerated in all patients. Among the seven patients, two were removed from the study at 3 months for clinical worsening and five evolved toward clinical, biological, and endoscopic remission with a restored vagal tone. These results provide the first evidence that VNS is feasible and appears as an effective tool in the treatment of active CD.


Crohn's disease; cholinergic anti-inflammatory pathway; heart rate variability; vagus nerve; vagus nerve stimulation

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