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Vet J. 2016 Apr;210:85-8. doi: 10.1016/j.tvjl.2015.12.008. Epub 2015 Dec 29.

Equine herpesvirus type 1 (EHV1) induces alterations in the immunophenotypic profile of equine monocyte-derived dendritic cells.

Author information

1
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, B-9820 Merelbeke, Belgium.
2
Department of Obstetrics, Reproduction and Herd Health, Faculty of Veterinary Medicine, Ghent University, B-9820 Merelbeke, Belgium.
3
Institut für Virologie, Freie Universität Berlin, 14163 Berlin, Germany.
4
Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, B-9820 Merelbeke, Belgium; Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA. Electronic address: grv23@cornell.edu.

Abstract

Equine herpesvirus 1 (EHV1) is an α-herpesvirus that can infect a variety of different cells in vitro and in vivo, including dendritic cells (DC) which are essential in the immune response against EHV1. Infection of equine monocyte-derived DC (MDDC) with EHV1 induced down-regulation of major histocompatibility complex I (MHCI), CD83, CD86, CD206, CD29 and CD172a, but not of CD11a/CD18 and MHCII. This down-regulation was not mediated by the virion host-shutoff (VHS) protein or pUL49.5. Interestingly, down-regulation of CD83 and CD86 was in part mediated by pUL56. Taken together, these data indicate that EHV1 employs different and still unresolved mechanisms to induce down-regulation of several functionally important cell surface proteins on equine DC.

KEYWORDS:

Down-regulation; Equine herpesvirus 1; Monocyte-derived dendritic cells; pUL56

PMID:
26920348
DOI:
10.1016/j.tvjl.2015.12.008
[Indexed for MEDLINE]

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