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Card Electrophysiol Clin. 2016 Mar;8(1):223-31. doi: 10.1016/j.ccep.2015.10.034.

The Muscle-Bound Heart.

Author information

1
Cardiac Electrophysiology, Cardiology, Department of Internal Medicine, American University of Beirut Faculty of Medicine and Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut Faculty of Medicine and Medical Center, PO Box 11-0236, Riad El-Solh, Beirut 1107 2020, Lebanon; Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon; Department of Internal Medicine, American University of Beirut, Beirut, Lebanon. Electronic address: mr48@aub.edu.lb.
2
Department of Genetics, Harvard Medical School, Boston, MA, USA; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
3
Department of Biochemistry and Molecular Genetics, American University of Beirut, Beirut, Lebanon.
4
Department of Internal Medicine, American University of Beirut, Beirut, Lebanon.
5
Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut, Lebanon.
6
Department of Genetics, Harvard Medical School, Boston, MA, USA.
7
Department of Genetics, Harvard Medical School, Boston, MA, USA; Division of Cardiology, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA, USA.

Abstract

Hypertrophic cardiomyopathy (HCM) is a familial cardiac disease manifested in a wide phenotype and diverse genotype and, thus, presenting unpredictable risks mainly on young adults. Extensive studies are being conducted to categorize patients and link phenotype with genotype for a better management and control of the disease with all its complications. Because the full mechanisms behind HCM are still not revealed, therapeutics are not definitive. Further research is to be conducted for the generation of a complete picture and directed therapy for HCM.

KEYWORDS:

Genotype; Hypertrophic cardiomyopathy; Left ventricle; Muscle-bound heart; Phenotype

PMID:
26920199
DOI:
10.1016/j.ccep.2015.10.034
[Indexed for MEDLINE]

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