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Nutr J. 2016 Feb 27;15:19. doi: 10.1186/s12937-016-0138-0.

Cow's milk-based beverage consumption in 1- to 4-year-olds and allergic manifestations: an RCT.

Author information

1
Federal University of Bahia, Salvador, Bahia, Brazil. pontes77@hotmail.com.
2
Federal University of Bahia, Salvador, Bahia, Brazil. ribeirot21@gmail.com.
3
Federal University of Bahia, Salvador, Bahia, Brazil. hugocrj@gmail.com.
4
Federal University of Bahia, Salvador, Bahia, Brazil. mattosangela@gmail.com.
5
Federal University of Bahia, Salvador, Bahia, Brazil. indhiralmeida@gmail.com.
6
Federal University of Bahia, Salvador, Bahia, Brazil. vivianmascarenhas@gmail.com.
7
Federal University of Bahia, Salvador, Bahia, Brazil. gabinutty@yahoo.com.br.
8
Mead Johnson Pediatric Nutrition Institute, Evansville, IN, USA. Suzanne.Stolz@mjn.com.
9
Mead Johnson Pediatric Nutrition Institute, Evansville, IN, USA. Weihong.Zhuang@mjn.com.
10
Mead Johnson Pediatric Nutrition Institute, Evansville, IN, USA. deolindascalabrin@gmail.com.

Abstract

BACKGROUND:

Nutrients such as docosahexaenoic acid (DHA), prebiotics and β-glucan have been associated with reduced incidence of respiratory illnesses and allergic manifestations (AM). Our objective was to assess if consumption of a cow's milk-based beverage with these and other nutrients supports respiratory, gastrointestinal, and skin health in otherwise well-nourished, healthy children.

METHODS:

In this double-blind, randomized, controlled trial, healthy children (1-4 years of age) from two daycare centers in Brazil were fed three servings/day of a cow's milk-based beverage (CMBB; n = 125) containing DHA, the prebiotics polydextrose (PDX) and galactooligosaccharides (GOS), β-glucan, and other key nutrients, or a control cow's milk-based beverage (control; n = 131) for up to 28 weeks. Occurrence of respiratory infections, diarrheal disease and AM was assessed by study pediatricians and the number of episodes were analyzed with the Cochran-Mantel-Haenszel test and the Andersen-Gill model.

RESULTS:

The CMBB group had fewer episodes of AM, which included allergic rhinitis or conjunctivitis, wheezing, allergic cough, eczema and urticaria, compared to the control group (p = 0.021). The hazard ratio for increased number of episodes of AM was lower in the CMBB group compared to control (HR, 0.64; 95 % CI 0.47-0.89; p = 0.007). There was no difference in the incidence of respiratory infections and diarrheal disease between groups.

CONCLUSION:

A cow's milk-based beverage containing DHA, PDX/GOS, and yeast β-glucan, and supplemented with micronutrients, including zinc, vitamin A and iron, when consumed 3 times/day for 28 weeks by healthy 1- to 4-year-old children was associated with fewer episodes of allergic manifestations in the skin and the respiratory tract.

TRIAL REGISTRATION:

registration number: NCT01431469.

PMID:
26920136
PMCID:
PMC4769487
DOI:
10.1186/s12937-016-0138-0
[Indexed for MEDLINE]
Free PMC Article

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