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Oncotarget. 2016 Mar 15;7(11):11860-3. doi: 10.18632/oncotarget.7644.

In normal aging ventricular system never attains pathological values of Evans' index.

Author information

1
Department of Neurology and Psychiatry, Neurosurgery, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
2
Department of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
3
Department of Neurology and Psychiatry, Endovascular Neurosurgery/Interventional Neuroradiology, "Sapienza" University of Rome, Rome, Italy.
4
Department of Radiology, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
5
Department of Public Health and Infectious Diseases, Medical Statistics and Biometry, "Sapienza" University of Rome, Rome, Italy.
6
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.
7
Department of Medico-Surgical Sciences and Biotechnologies, Neurology, A. Fiorini Hospital, Terracina, LT, "Sapienza" University of Rome, Polo Pontino, Italy.

Abstract

Ventricular enlargement in normal aging frequently forces the radiological diagnosis of hydrocephalus, but the reliability of Evans' index as a radiological marker of abnormal ventricular enlargement (values > 0.30) during aging is not assessed. Here we analyze ventricular size during aging and the reliability of Evans' index as a radiological marker of abnormal ventricular enlargement. We calculated Evans' index in the axial Computed Tomography scans of 1221 consecutive individuals (aged 45-101 years) from an emergency department. Stratified analysis of one-year cohorts showed that the mean Evans' index value per class was invariably < 0.30. Roughly one out five Computed Tomography scans was associated with Evans' index values > 0.30 and Evans' index values increased with age. The risk of having an Evans' index value > 0.30 increased by 7.8% per year of age (p < 0.001) and males were at 83.9% greater risk than females (p < 0.001). Overall, this study shows that normal aging enlarges the ventricular system, but never causes abnormal ventricular enlargement. Evans' index values > 0.30 should reflect an underlying neurological condition in every individual.

KEYWORDS:

Evans’ index; Gerotarget; aging; brain; enlargement; ventricular system

PMID:
26919252
PMCID:
PMC4914253
DOI:
10.18632/oncotarget.7644
[Indexed for MEDLINE]
Free PMC Article

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