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Oncotarget. 2016 Mar 15;7(11):12053-62. doi: 10.18632/oncotarget.7641.

Elevated expression of HIF-lα in actively growing prostate tissues is associated with clinical features of benign prostatic hyperplasia.

Author information

1
Department of Urology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
2
Department of Urology, Huashan Hospital, Fudan University, Shanghai, China.
3
Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Abstract

BACKGROUND:

Benign prostatic hyperplasia (BPH) is one of the most common diseases in middle-age or older men. Increasing evidence has shown that BPH is associated with hypoxia microenvironment.

METHODS:

We retrospectively collected patient data and tissue samples from fetal prostates(FP), normal prostates(NP), intra-acinar of BPH, peri-acinar of BPH, prostate cancers and sarcomas of prostate. The expression of HIF-1α, as well as VEGF was visualized by immunohistochemistry and statistically analyzed with clinical parameters.

RESULTS:

Expression of HIF-lα was observed in intra-acinar of BPH (69.5%), prostate cancer (85.7%) and all FPs, while NP and peri-acinar of BPH tissues were all stained negative. HIF-lα levels in FPs and the malignant tumors were higher than BPH tissues(p < 0.05), and the expression of HIF-lα in intra-acinar of BPH was higher than NP and peri-acinar of BPH (p < 0.05). The expression of HIF-lα was correlated with the weight of intra-acinar of prostate (p < 0.05). And patients with prostate weight larger that 72.45g were prone to have HIF-lα moderate-positive expression, according to the ROC curve (AUC = 0.734, 95%CI = 0.630-0.838). Moreover, the risk of acute urine retention (AUR) for HIF-lα moderate-positive patients increased significantly (OR=5.517, 95%CI = 2.434-12.504).

CONCLUSIONS:

HIF-lα expression is increased in highly proliferative prostate tissues and correlated with the weight of intra-acinar prostate. Moreover, HIF-lα is also an independent risk factor for AUR occurrence in BPH patients.

KEYWORDS:

Pathology Section; acute urine retention(AUR); benign prostatic hyperplasia(BPH); fetal prostate(FP); hypoxia inducible factor-1alpha(HIF-lα)

PMID:
26919249
PMCID:
PMC4914268
DOI:
10.18632/oncotarget.7641
[Indexed for MEDLINE]
Free PMC Article

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