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Innovations (Phila). 2016 Jan-Feb;11(1):59-63; discussion 63. doi: 10.1097/IMI.0000000000000240.

A Plasma-Based, Amiodarone-Impregnated Material Decreases Susceptibility to Atrial Fibrillation in a Post-Cardiac Surgery Model.

Author information

1
From the *Heart, Lung and Vascular Medicine Institute and †Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA USA; ‡Carmell Therapeutics Corporation, Pittsburgh, PA USA; and §Institute for Complex Engineered Systems, ∥Robotics Institute, and ¶Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA USA.

Abstract

OBJECTIVE:

This study aimed to test the impact of a plasma-based, material (PBM) impregnated with amiodarone on atrial electrophysiology and atrial fibrillation susceptibility in a porcine post-cardiac surgery model.

METHODS:

Ten healthy pigs underwent implantation of transvenous pacing systems, after which sterile talc was infused into the pericardial sac via a pericardiotomy. In five animals, PBM was applied to the atrial epicardial surface just before talc infusion. Electrophysiologic evaluations were performed using the pacing system immediately after chest closure and 7 days later. Atrial histologic evaluations were performed.

RESULTS:

Immediately after chest closure, there were no significant differences in electrophysiologic parameters between talc-only and talc + PBM animals, and atrial fibrillation was largely noninducible. On postsurgical day 7, electrophysiologic evaluation revealed significantly shorter sinus cycle length and atrioventricular nodal refractoriness among talc-only animals relative to talc + PBM animals, possibly suggesting attenuated sympathetic nervous system activation in the latter. Atrial fibrillation inducibility and duration were significantly greater among talc-only animals. No significant differences in atrial refractoriness or conduction time between groups were apparent. Histologic evaluation revealed a relative reduction in epicardial inflammation and less myolysis among talc + PBM animals.

CONCLUSIONS:

Epicardial application of a plasma-based, amiodarone-impregnated material was associated with a significant reduction in atrial inflammation and susceptibility to fibrillation.

PMID:
26918312
DOI:
10.1097/IMI.0000000000000240
[Indexed for MEDLINE]

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