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Clin Oral Investig. 2017 Jan;21(1):111-120. doi: 10.1007/s00784-016-1759-6. Epub 2016 Feb 26.

Electrical stimulation enhances tissue reorganization during orthodontic tooth movement in rats.

Author information

1
Graduate Program of Orthodontics, Heminio Ometto University Center, UNIARARAS, Dr. Maximiliano Baruto, 500, Araras, SP, 13607-339, Brazil.
2
School of Dentistry, Heminio Ometto University Center, UNIARARAS, Dr. Maximiliano Baruto, 500, Araras, SP, 13607-339, Brazil.
3
Division of Periodontics, College of Dentistry, State University of São Paulo, UNESP, Av. Eng. Francisco José Longo, 777, São José dos Campos, SP, 12245-000, Brazil.
4
Graduate Program of Biomedical Sciences, Heminio Ometto University Center, UNIARARAS, Dr. Maximiliano Baruto, 500, Araras, SP, 13607-339, Brazil.
5
Graduate Program of Orthodontics, Heminio Ometto University Center, UNIARARAS, Dr. Maximiliano Baruto, 500, Araras, SP, 13607-339, Brazil. santamariajr@mailcity.com.
6
Graduate Program of Biomedical Sciences, Heminio Ometto University Center, UNIARARAS, Dr. Maximiliano Baruto, 500, Araras, SP, 13607-339, Brazil. santamariajr@mailcity.com.

Abstract

OBJECTIVE:

This study evaluated the effects of a low-intensity electric current on tissue reorganization during experimental orthodontic tooth movement.

MATERIALS AND METHODS:

Thirty-two animals were divided into two groups evaluated on days 3 and 7: OTM-orthodontic tooth movement and OTM + MC-orthodontic tooth movement and microcurrent application (10 μA/5 min). The samples were processed for histological, morphometric, and Western blotting analysis.

RESULTS:

Analysis of the periodontal ligament (PL) showed a significantly smaller number of granulocytes in the OTM + MC group on day 7.The number of fibroblasts was significantly higher in the OTM + MC group on days 3 and 7. The area of birefringent collagen fibers was more organized in the OTM + MC group on days 3 and 7. The number of blood vessels was significantly higher in the OTM + MC group on day 7. Microcurrent application significantly increased the number of osteoclasts in the compression region of the PL. In the OTM + MC group on day 7 of tooth movement, the expression of TGF-β1 and VEGF was significantly reduced whereas the expression of bFGF was increased in PL.

CONCLUSIONS:

Electrical stimulation enhances tissue responses, reducing the number of granulocytes and increasing the number of fibroblasts, blood vessels, and osteoclasts and modulates the expression of TGF-β1, VEFG, and bFGF.

CLINICAL RELEVANCE:

This technique is used in many areas of medicine, but poorly explored in dentistry and orthodontics. This treatment is cheap and non-invasive and can be applied by own orthodontist, and it can improve the treatment with a faster and safe tooth movement, without pain.

KEYWORDS:

Low-intensity electric current; Microcurrent application; Orthodontic tooth movement

PMID:
26917494
DOI:
10.1007/s00784-016-1759-6
[Indexed for MEDLINE]

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