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Tumori. 2016 Mar-Apr;102(2):162-7. doi: 10.5301/tj.5000478. Epub 2016 Feb 19.

The role of radiotherapy in local control of nonextremity Ewing sarcomas.

Author information

1
Department of Radiation Oncology, Faculty of Medicine, Ege University, Izmir - Turkey.
2
Department of Orthopedics and Traumatology, Faculty of Medicine, Ege University, Izmir - Turkey.
3
Department of Pediatric Oncology, Dr. Behçet Uz Children's Hospital, Izmir - Turkey.
4
Department of Pediatric Oncology, Tepecik Training and Research Hospital, Izmir - Turkey.
5
Department of Pediatric Oncology, Ege University Faculty of Medicine, Izmir - Turkey.

Abstract

PURPOSE:

To evaluate the results of radiotherapy and the prognostic factors affecting local control in nonextremity Ewing sarcomas.

METHODS:

Between 1995 and 2011, 44 patients with nonextremity Ewing sarcomas were treated with radiotherapy. Tumor localizations were pelvis in 23, spine in 13, thoracic region in 5, and cranium in 3 patients. Tumor size was ≥8 cm in 56.8% of patients. Distant metastases were present in 19 of the patients at the time of diagnosis (43.1%). All patients were treated with 12 weeks of neoadjuvant chemotherapy followed by surgery and radiotherapy (45-54 Gy) or radiotherapy alone (54-64.8 Gy). Radiotherapy was applied due to microscopic residue (R1) in 5 patients after the operation and macroscopic tumor in 39 patients (macroscopic residue [R2] and nonresectable tumor).

RESULTS:

Median follow-up was 49 months (range 9-195). Local failures developed in 7 patients (15.9%) and local control at 5 years was 81.4%. Local recurrence was detected in 6 patients (6/38) who did not have residual tumor after RT. Progression was detected in 1 patient (1/6) who had residual tumor. All those patients with local failure experienced further distant metastases. Possible prognostic factors such as age (≤17 vs >17), tumor localization, tumor volume (≤8 cm vs >8 cm), and M status at diagnosis (0 vs 1) were not related to local control.

CONCLUSIONS:

Radiotherapy, either alone or adjuvant to surgery, provides local control in 80% of nonextremity Ewing sarcomas and plays an important role in treatment.

PMID:
26917407
DOI:
10.5301/tj.5000478
[Indexed for MEDLINE]

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