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Neuroradiol J. 2016 Apr;29(2):137-45. doi: 10.1177/1971400915628019. Epub 2016 Feb 25.

Perinatal MRI diffusivity is related to early assessment of motor performance in preterm neonates.

Author information

1
Department of Neuroscience and Imaging, G d'Annunzio University, Chieti, Italy Institute of Advanced Biomedical Technologies (ITAB), G d'Annunzio University, Chieti, Italy r.navarra@itab.unich.it.
2
Department of Neuroscience and Imaging, G d'Annunzio University, Chieti, Italy Institute of Advanced Biomedical Technologies (ITAB), G d'Annunzio University, Chieti, Italy.
3
Department of Neonatology, San Salvatore Hospital, L'Aquila, Italy.
4
Department of Pediatrics and Neonatology, G d'Annunzio University, Chieti, Italy.
5
Department of Medicine and Aging Sciences, G d'Annunzio University, Chieti, Italy.

Abstract

Preterm neonates represent a high-risk population for abnormal neuropsychological development. But presently, an accurate method for identifying those at risk is not available. This study evaluated the association between the microstructural organization measured with Diffusion Tensor Imaging (DTI) in term-corrected preterm neonates and subsequent motor performance. Fractional anisotropy (FA), axial diffusion (AD), mean diffusivity (MD) and radial diffusivity (RD) were determined in two regions of interest (ROIs) corresponding to the posterior limb of the internal capsule (PLIC) and cortico-spinal tract (CST). The Griffiths Mental Developmental Scales (GMDS) were longitudinally administered at 3, 6 and 15 months; and correlations between the metrics of diffusivity and the motor subscale of the GMDS were assessed using the Spearman correlation. A statistically significant negative correlation was observed between the AD of PLIC of the left hemisphere and the 3-month GMDS Locomotor Subscale. These results suggested that AD is a valid indicator of the stage of maturation of the motor pathway in preterm neonates, but not of later motor outcome.

KEYWORDS:

Axial diffusion; diffusion tensor imaging; fetal development; motor outcome; motor system; neurological development; neurological indicators; preterm neonates

PMID:
26915895
PMCID:
PMC4978313
DOI:
10.1177/1971400915628019
[Indexed for MEDLINE]
Free PMC Article

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