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Science. 2016 Feb 19;351(6275):854-7. doi: 10.1126/science.aad8588.

Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition.

Author information

1
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.
2
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.
3
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Ecole Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, Unité Mixte de Recherche 5242, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.
4
Laboratory of Gnotobiology, Institute of Microbiology of the Czech Academy of Sciences, v. v. i., Novy Hradek, Czech Republic.
5
UMR203 BF2I, Biologie Fonctionnelle Insectes et Interactions, Université de Lyon, INRA, INSA-Lyon, F-69621 Villeurbanne, France.
6
Laboratoire CarMeN, Université Lyon 1, Unité Mixte de Recherche INSERM U-1060 et INRA U-1397, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France.

Abstract

In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic hormone axis to drive systemic growth. Using monocolonized mouse models, we showed that selected lactobacilli promoted juvenile growth in a strain-dependent manner that recapitulated the microbiota's effect on growth and the somatotropic axis. These findings show that the host's microbiota supports juvenile growth. Moreover, we discovered that lactobacilli strains buffered the adverse effects of chronic undernutrition on the postnatal growth of germ-free mice.

PMID:
26912894
DOI:
10.1126/science.aad8588
[Indexed for MEDLINE]
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