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In Vivo. 2016 Mar-Apr;30(2):83-9.

Decreased Numbers of CD57+CD3- Cells Identify Potential Innate Immune Differences in Patients with Autism Spectrum Disorder.

Author information

1
Department of Experimental Medicine, Second University of Naples, Naples, Italy Centre for Autism - La Forza del Silenzio, Caserta, Italy Cancellautismo - Non-profit Association for Autism Care, Florence, Italy dariosin@uab.edu.
2
R.E.D. Laboratories, Zellik, Belgium.
3
Biomedical Centre for Autism Research and Treatment, Bari, Italy.
4
2 Department of Internal Medicine, Faculty of Medicine, Masaryk University, Brno, Czech Republic Laboratory of Structural Biology and Proteomics, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
5
Nevada Center for Biomedical Research, Reno, NV, U.S.A.
6
Himmunitas vzw, Brussels, Belgium.

Abstract

BACKGROUND/AIM:

Autism spectrum disorders (ASD) are complex, and severe heterogeneous neurodevelopmental pathologies with accepted but complex immune system abnormalities. Additional knowledge regarding potential immune dysfunctions may provide a greater understanding of this malady. The aim of this study was to evaluate the CD57(+)CD3(-) mature lymphocyte subpopulation of natural killer cells as a marker of immune dysfunction in ASD.

MATERIALS AND METHODS:

Three-color flow cytometry-based analysis of fresh peripheral blood samples from children with autism was utilized to measure CD57(+)CD3(-) lymphocytes.

RESULTS:

A reduction of CD57(+)CD3(-) lymphocyte count was recorded in a significant number of patients with autism.

DISCUSSION AND CONCLUSION:

We demonstrated that the number of peripheral CD57(+)CD3(-) cells in children with autism often falls below the clinically accepted normal range. This implies that a defect in the counter-regulatory functions necessary for balancing pro-inflammatory cytokines exists, thus opening the way to chronic inflammatory conditions associated with ASD.

KEYWORDS:

Autism; CD57+CD3− lymphocytes; HNK-1; immune dysfunction

PMID:
26912817
[Indexed for MEDLINE]

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