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Int J Surg Pathol. 2016 Aug;24(5):394-400. doi: 10.1177/1066896916633856. Epub 2016 Feb 23.

Interleukin-33 Expression Indicates a Favorable Prognosis in Malignant Salivary Gland Tumors.

Author information

1
Institute of Pathology, Cantonal Hospital of Grisons, Chur, Switzerland.
2
Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland.
3
Novartis Institute for Biomedical Research, Basel, Switzerland.
4
Cantonal Cancer Registry Zürich-Zug, Zürich, Switzerland.
5
Institute of Surgical Pathology, University Hospital Zürich, Zürich, Switzerland.
6
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zürich, Zürich, Switzerland.
7
Institute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland kirsten.mertz@ksbl.ch.

Abstract

The cytokine interleukin-33 (IL-33) is abundantly expressed in epithelial barrier tissues such as salivary glands. Here, we characterized nuclear IL-33 protein expression by immunohistochemistry in benign and malignant salivary gland tumors and associated it with disease outcome. Most benign salivary gland tumors expressed IL-33, and all Warthin's tumors showed strong and consistent IL-33 expression in the basally oriented cells of their bilayered epithelium. In the malignant group of neoplasms, nuclear IL-33 expression was limited to specific tumor entities-for example, to epithelial-myopepithelial carcinomas (n = 9/11), acinic cell carcinomas (n = 13/27), and oncocytic carcinomas (n = 2/2). IL-33 expression in the combined group of malignant salivary gland neoplasms was significantly associated with favorable histological parameters, lack of metastasis, and longer overall survival, compared with IL-33-negative tumors. We conclude that IL-33 expression is a novel prognostic marker for malignant salivary gland tumors with potential use in clinical diagnostics.

KEYWORDS:

biomarker; immunohistochemistry; interleukin-33; prognosis; salivary gland; tissue microarray

PMID:
26912475
DOI:
10.1177/1066896916633856
[Indexed for MEDLINE]

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