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Artif Cells Nanomed Biotechnol. 2017 Mar;45(2):233-241. doi: 10.3109/21691401.2016.1146727. Epub 2016 Feb 25.

Bioactive PLGA-curcumin microparticle-embedded chitosan scaffold: in vitro and in vivo evaluation.

Author information

1
a Department of Pharmaceutics , Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
2
b Department of Pharmaceutical Biotechnology , Manipal College of Pharmaceutical Sciences, Manipal University , Manipal , Karnataka , India.
3
c Department of Pharmacology , Melaka Manipal Medical College and Center for Integrative Medicine & Research, Manipal University , Manipal , Karnataka , India.
4
d Directorate of Research , Manipal University , Manipal , Karnataka , India.

Abstract

Wound healing is a complex process affected by several factors. In the present work, novel biocompatible PLGA-curcumin microparticle-embedded chitosan scaffold was fabricated for wound-healing application. Process variables involved in the preparation of microparticles were optimized using design of experiment. Scanning electron microscopy (SEM) confirmed the porous nature of scaffold with embedded microparticles. A maximum release of 14% of the encapsulated curcumin was observed at 12th hour. Modified tube dilution method showed that scaffold significantly (pā€‰<ā€‰0.05) reduced multiplication of Staphylococcus aureus. More than 50% of the excised wound in rats healed in 4 days with an epithilization period of 18 days.

KEYWORDS:

Chitosan scaffold; curcumin microparticles; design of experiments; tissue regeneration; wound healing

PMID:
26912183
DOI:
10.3109/21691401.2016.1146727
[Indexed for MEDLINE]

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