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J Agric Food Chem. 2016 Mar 16;64(10):2053-61. doi: 10.1021/acs.jafc.5b06157. Epub 2016 Mar 7.

Prevention of Obesity and Type 2 Diabetes with Aged Citrus Peel (Chenpi) Extract.

Author information

1
Department of Food Science, Rutgers University , 65 Dudley Road, New Brunswick, New Jersey 08901, United States.
2
Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School , Piscataway, New Jersey 08854, United States.
3
College of Food Science, South China Agricultural University , Guangzhou 510642, People's Republic of China.

Abstract

Chenpi is the dry peel of the plant Citrus reticulata Blanco after an aging processing. It has been used as an antidigestive and anti-inflammatory traditional medicine, as well as culinary seasoning and dietary supplement, in China. However, its efficacy and underlying scientific mechanism have not been sufficiently investigated. Chenpi is uniquely enriched with a high content of 5-demethylated polymethoxyflavones (5-OH PMFs). The effect of chenpi extract on improving metabolic features was examined using high-fat diet (HFD)-induced obesity/diabetes mouse model. Oral administration of 0.25 and 0.5% chenpi extract in food over 15 weeks markedly prevented HFD-induced obesity, hepatic steatosis, and diabetic symptoms. The beneficial effect is associated with 5'-adenosine monophosphate-activated protein kinase (AMPK) activation in adipose tissue. Our results indicate that 5-OH PMFs-enriched chenpi extract is effective in preventing obesity and type 2 diabetes, and its effect might be related to improvement in lipid metabolism associated with activation of the AMPK pathway.

KEYWORDS:

5-demethylated polymethoxyflavones; chenpi; diabetes; insulin resistance; obesity

PMID:
26912037
DOI:
10.1021/acs.jafc.5b06157
[Indexed for MEDLINE]

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