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J Agric Food Chem. 2016 Mar 16;64(10):2053-61. doi: 10.1021/acs.jafc.5b06157. Epub 2016 Mar 7.

Prevention of Obesity and Type 2 Diabetes with Aged Citrus Peel (Chenpi) Extract.

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Department of Food Science, Rutgers University , 65 Dudley Road, New Brunswick, New Jersey 08901, United States.
Department of Pharmacology, Rutgers University-Robert Wood Johnson Medical School , Piscataway, New Jersey 08854, United States.
College of Food Science, South China Agricultural University , Guangzhou 510642, People's Republic of China.


Chenpi is the dry peel of the plant Citrus reticulata Blanco after an aging processing. It has been used as an antidigestive and anti-inflammatory traditional medicine, as well as culinary seasoning and dietary supplement, in China. However, its efficacy and underlying scientific mechanism have not been sufficiently investigated. Chenpi is uniquely enriched with a high content of 5-demethylated polymethoxyflavones (5-OH PMFs). The effect of chenpi extract on improving metabolic features was examined using high-fat diet (HFD)-induced obesity/diabetes mouse model. Oral administration of 0.25 and 0.5% chenpi extract in food over 15 weeks markedly prevented HFD-induced obesity, hepatic steatosis, and diabetic symptoms. The beneficial effect is associated with 5'-adenosine monophosphate-activated protein kinase (AMPK) activation in adipose tissue. Our results indicate that 5-OH PMFs-enriched chenpi extract is effective in preventing obesity and type 2 diabetes, and its effect might be related to improvement in lipid metabolism associated with activation of the AMPK pathway.


5-demethylated polymethoxyflavones; chenpi; diabetes; insulin resistance; obesity

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