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Nat Cell Biol. 2016 Mar;18(3):257-9. doi: 10.1038/ncb3321.

Chromosomes at loose ends.

Author information

1
Department of Biology and Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, USA.

Abstract

Broken ends of a budding yeast chromosome exhibit increased mobility, presumably to facilitate repair by recombination. A new study reports that increased mobility reflects the untethering of the broken chromosome, triggered by a DNA damage response that phosphorylates the Cep3 kinetochore protein and weakens the association between the centromere and the spindle pole body.

PMID:
26911910
DOI:
10.1038/ncb3321
[Indexed for MEDLINE]

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