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Nat Cell Biol. 2016 Mar;18(3):246-54. doi: 10.1038/ncb3312.

Organoids as an in vitro model of human development and disease.

Author information

1
A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.
2
Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, Edinburgh, EH16 4TJ, UK.
3
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.

Abstract

The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.

PMID:
26911908
DOI:
10.1038/ncb3312
[Indexed for MEDLINE]
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