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Nat Commun. 2016 Feb 25;7:10763. doi: 10.1038/ncomms10763.

Calcium imaging of sleep-wake related neuronal activity in the dorsal pons.

Author information

1
Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, 230 Li Ka Shing Center, Berkeley, California 94720, USA.

Abstract

The dorsal pons has long been implicated in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain poorly understood. Using cell-type-specific microendoscopic Ca(2+) imaging in and near the laterodorsal tegmental nucleus, we found that many glutamatergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neurons are maximally active during wakefulness (wake-max). Furthermore, the activity of glutamatergic neurons exhibits a medio-lateral spatial gradient, with medially located neurons more selectively active during REM sleep.

PMID:
26911837
PMCID:
PMC4773416
DOI:
10.1038/ncomms10763
[Indexed for MEDLINE]
Free PMC Article

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