Abstract
New antimicrobials with novel mechanisms need to be developed to combat antimicrobial-resistant pathogenic bacteria. The current authors recently reported discovery of a new antibiotic named "Lysocin E". Lysocin E was identified using a silkworm model of bacterial infection. The current review discusses the advantages of using a silkworm model of bacterial infection to identify and develop therapeutically efficacious antimicrobials. This review also discusses the discovery of lysocin E and its novel mechanism of action.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Bacterial Infections / drug therapy*
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Bacterial Infections / microbiology
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Bombyx / drug effects*
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Bombyx / embryology
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Bombyx / microbiology
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Disease Models, Animal
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Drug Discovery / methods*
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Drug Resistance, Multiple, Bacterial
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Humans
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Larva / drug effects
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Larva / microbiology
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Molecular Structure
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Peptides, Cyclic / pharmacology*
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Species Specificity
Substances
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Anti-Bacterial Agents
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Peptides, Cyclic
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lysocin E