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Arch Endocrinol Metab. 2016 Feb 23;60(3):190-8. doi: 10.1590/2359-3997000000134.

Association of polymorphisms within the Renin-Angiotensin System with metabolic syndrome in a cohort of Chilean subjects.

Author information

1
Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera (BIOREN-UFRO), Temuco, Chile.
2
Departamento de Ciencias Preclínicas, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile.
3
Faculty of Health Sciences, Universidad Católica de Temuco, Temuco, Chile.
4
Departamento de Medicina Interna, Faculty of Medicine, Universidad de La Frontera, Temuco, Chile.

Abstract

OBJECTIVE:

Metabolic syndrome (MetS) is associated with hypertension, obesity and dyslipidemia. Thus, genetic variants related with these conditions may modulate its development. We evaluated the effect of polymorphisms in the renin-angiotensin system (RAS) on metabolic syndrome risk in a cohort of Chilean subjects.

SUBJECTS AND METHODS:

A total of 152 subjects, 83 with MetS (51.2 ± 9.6 years) and 69 without MetS (49.5 ± 9.3 years) of both genders were included, according to the ATP III update criteria. The rs4340 Insertion/Deletion (I/D), rs699 (T>C) and rs5186 (A>C) of the ACE, AGT and AGTR1 genes, respectively, were genotyped.

RESULTS:

After adjusting for age and gender, we observed the DD genotype of rs4340 associated with MetS (p = 0.02). Specifically, the DD genotype was associated with MetS risk in women (OR = 4.62, 95%CI, 1.41 - 15.04; p < 0.01). In males, the AA genotype for rs5186 variant was associated with an increased risk for developing MetS when compared with women carrying the same genotype (OR = 3.2; 95%CI, 1.03 - 9.89; p = 0.04). In subjects without MetS, DD genotype was associated with increased waist circumference (p = 0.023) while subjects with MetS carrying the rs5186 TT genotype showed higher levels of HDL-cholesterol (p = 0.031).

CONCLUSION:

The present study contributes data highlighting the role for RAS polymorphisms in predisposing to metabolic syndrome in Chilean subjects.

PMID:
26910623
DOI:
10.1590/2359-3997000000134
[Indexed for MEDLINE]
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